{"id":1458,"date":"2026-05-07T12:48:10","date_gmt":"2026-05-07T09:48:10","guid":{"rendered":"https:\/\/gynaikologos-komotini.gr\/?p=1458"},"modified":"2026-05-07T12:55:47","modified_gmt":"2026-05-07T09:55:47","slug":"premature-over-yetmezligi-poy","status":"publish","type":"post","link":"https:\/\/gynaikologos-komotini.gr\/tr\/premature-over-yetmezligi-poy\/","title":{"rendered":"Premat\u00fcre Over Yetmezli\u011fi (POY)"},"content":{"rendered":"\t\t
\n\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Premat\u00fcre over yetmezli\u011fi (POY), 40 ya\u015f alt\u0131ndaki kad\u0131nlar\u0131n %1\u2019inde g\u00f6r\u00fcl\u00fcr. Bu ya\u015f\u0131n alt\u0131nda adet g\u00f6rmeyen bir kad\u0131nda POY bulunma olas\u0131l\u0131\u011f\u0131 ise %5\u201310\u2019dur.<\/p>

Yumurtal\u0131klar normalde bir yandan hormon (\u00f6strojen, progesteron, androjen) \u00fcretmek, di\u011fer yandan da ovulasyon i\u00e7in folik\u00fcl \u00fcretmek \u00fczere programlanm\u0131\u015ft\u0131r. Fet\u00fcs\u00fcn gebeli\u011finin 20. haftas\u0131nda folik\u00fcl say\u0131s\u0131 yakla\u015f\u0131k 6\u20137 milyon iken, kad\u0131n \u00fcreme \u00e7a\u011f\u0131na girdi\u011finde bu say\u0131 yakla\u015f\u0131k 300\u2013400 bine d\u00fc\u015fer ve bunlar yakla\u015f\u0131k 51 ya\u015f\u0131na kadar, yani menopoz ya\u015f\u0131na kadar kullan\u0131l\u0131r. Bu s\u00fcrecin 40 ya\u015f\u0131ndan \u00f6nce ger\u00e7ekle\u015fmesine premat\u00fcre over yetmezli\u011fi denir.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Nedenler<\/h2>

Nedenler \u00e7ok \u00e7e\u015fitlidir (genetik, otoimm\u00fcn, inflamatuvar, \u00e7evresel ve iyatrojenik). Bununla birlikte vakalar\u0131n %70\u201390\u2019\u0131 idiopatiktir (hastalar\u0131n daha iyi genetik de\u011ferlendirilmesi sayesinde bu oran %39\u201367\u2019ye d\u00fc\u015fme e\u011filimindedir).<\/p>

Vakalar\u0131n %30\u2019unda ailede over yetmezli\u011fi \u00f6yk\u00fcs\u00fc bulunur ve bu durumda genetik nedenler (Turner sendromu, X trisomisi, frajil X premutasyonu, monogenik bozukluklar) g\u00fc\u00e7l\u00fc \u015fekilde d\u00fc\u015f\u00fcn\u00fclmeli ve ara\u015ft\u0131r\u0131lmal\u0131d\u0131r.<\/p>

Otoimm\u00fcn mekanizmalar vakalar\u0131n %4\u201330\u2019unu olu\u015fturur. En s\u0131k ili\u015fkili hastal\u0131klar Hashimoto tiroiditi, Addison hastal\u0131\u011f\u0131, Sj\u00f6gren sendromu, tip 1 diyabet ve inflamatuvar ba\u011f\u0131rsak hastal\u0131klar\u0131d\u0131r (Crohn hastal\u0131\u011f\u0131, \u00fclseratif kolit). POY, adrenal yetmezli\u011fin erken belirtisi olabilir; \u00e7\u00fcnk\u00fc 21-hidroksilaz otoantikorlar\u0131 yumurtal\u0131klarda folik\u00fcl y\u0131k\u0131m\u0131na ve ooforite yol a\u00e7ar.<\/p>

POY\u2019ye neden olabilecek di\u011fer \u00e7evresel fakt\u00f6rler aras\u0131nda sigara, konserve g\u0131dalarda ve plastiklerde bulunan ve \u00f6strojeni taklit eden bisfenol A, plastikleri esnek hale getirmek i\u00e7in kullan\u0131lan ve yumurtal\u0131klar i\u00e7in toksik olan ftalatlar, ayr\u0131ca kirli su veya kirlenmi\u015f g\u0131dalar yoluyla al\u0131nan a\u011f\u0131r metaller (arsenik, kadmiyum, c\u0131va) yer al\u0131r. Poliklorlu bifeniller 1970\u2019lerden beri yasaklanm\u0131\u015f olmas\u0131na ra\u011fmen \u00e7evrede h\u00e2l\u00e2 bulunmaktad\u0131r.<\/p>

\u0130yatrojenik nedenler aras\u0131nda bir\u00e7ok kemoterapi ilac\u0131 (\u00f6zellikle alkilleyici ajanlar), radyasyon tedavisi ve her iki yumurtal\u0131\u011f\u0131n cerrahi olarak \u00e7\u0131kar\u0131lmas\u0131 bulunur. Kemoterapi sonras\u0131 \u00e7ocuklar\u0131n %10,9\u201318,6\u2019s\u0131nda POY geli\u015fmektedir. Kemoterapi ve hipofiz\/pelvis b\u00f6lgesine uygulanan radyasyonun etkisi doza ba\u011f\u0131ml\u0131d\u0131r.<\/p>

Enfeksiyonlar vakalar\u0131n %1\u20135\u2019inden sorumludur. Kabakulak en s\u0131k nedendir; \u00e7\u00fcnk\u00fc ergenlik sonras\u0131 k\u0131zlar\u0131n %5\u2019inde ooforit geli\u015fir. Daha nadir nedenler aras\u0131nda t\u00fcberk\u00fcloz, HIV, su\u00e7i\u00e7e\u011fi, s\u0131tma ve sitomegalovir\u00fcs bulunur.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

\n\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t\t\t

Klinik Bulgular, Ay\u0131r\u0131c\u0131 Tan\u0131 ve De\u011ferlendirme<\/h2>

POY\u2019nin klinik tablosu menopozdan farkl\u0131d\u0131r; \u00e7\u00fcnk\u00fc kal\u0131c\u0131 adet kesilmesi yerine d\u00fczensiz veya aral\u0131kl\u0131 adet g\u00f6rme s\u00f6z konusudur.<\/p>

Ergenlikte \u015fu \u015fekillerde ortaya \u00e7\u0131kabilir:<\/p>

  • Gecikmi\u015f puberte (meme geli\u015fiminin olmamas\u0131)<\/li>
  • Primer amenore (15 ya\u015f\u0131na kadar adet ba\u015flamamas\u0131)<\/li>
  • Sekonder amenore<\/li>
  • Oligomenore (< y\u0131lda 4 adet d\u00f6ng\u00fcs\u00fc)<\/li><\/ul>

    Her ya\u015fta a\u015fa\u011f\u0131daki belirtiler g\u00f6r\u00fclebilir:<\/p>

    • Vazomotor semptomlar (ate\u015f basmas\u0131, gece terlemeleri)<\/li>
    • Vajinal kuruluk<\/li>
    • Disparoni<\/li>
    • Ruh hali de\u011fi\u015fiklikleri (sinirlilik, anksiyete, depresyon)<\/li>
    • Uyku bozukluklar\u0131<\/li>
    • Yorgunluk<\/li>
    • Libido azalmas\u0131<\/li>
    • Konsantrasyon bozuklu\u011fu<\/li><\/ul>

      POY ayr\u0131ca uzun vadede osteoporoz ve kardiyovask\u00fcler hastal\u0131k riskleriyle ili\u015fkilidir.<\/p>

      Ergenlikte d\u00fczensiz sikluslar ba\u015flang\u0131\u00e7ta hipotalamo-hipofizer aks\u0131n olgunla\u015fmam\u0131\u015f olmas\u0131na ba\u011fl\u0131 olabilir; ancak devam ederse POY d\u00fc\u015f\u00fcn\u00fclmelidir. POY, primer amenorenin %10\u201328\u2019inden ve sekonder amenorenin %4\u201348\u2019inden sorumludur. Vazomotor semptomlar bu ya\u015f grubunda \u00e7ok nadirdir.<\/p>

      Tan\u0131, d\u00fc\u015f\u00fck estradiol (<50 pg\/ml) ile birlikte iki ayr\u0131 \u00f6l\u00e7\u00fcmde (4 hafta arayla) y\u00fcksek gonadotropin d\u00fczeyleri (FSH, LH >25 IU\/L) saptanmas\u0131yla konur.<\/p>

      Ay\u0131r\u0131c\u0131 tan\u0131da:<\/p>

      • Hipotalamik amenore (normal gonadotropinler)<\/li>
      • Polikistik over sendromu (normal\/hafif y\u00fcksek gonadotropinler, y\u00fcksek androjenler)<\/li>
      • Tiroid bozukluklar\u0131 (anormal TSH ve FT4)<\/li>
      • Gebelik (y\u00fcksek \u03b2-HCG)<\/li>
      • Hiperprolaktinemi<\/li>
      • Adrenal hiperplazi (\u00e7ok y\u00fcksek androjenler)<\/li><\/ul>

        de\u011ferlendirilmelidir.<\/p>

        Hastan\u0131n \u00f6yk\u00fcs\u00fc olduk\u00e7a \u00f6nemlidir \u00e7\u00fcnk\u00fc yukar\u0131daki nedenlerden birini ortaya \u00e7\u0131karabilir. Fizik muayenede \u00f6zellikle ergenlerde:<\/p>

        • Primer cinsiyet \u00f6zellikleri (aksiller ve pubik k\u0131llanma)<\/li>
        • Sekonder cinsiyet \u00f6zellikleri (meme geli\u015fimi)<\/li>
        • B\u00fcy\u00fcme e\u011frileri<\/li>
        • BMI<\/li>
        • Hiperandrojenizm bulgular\u0131 (hirsutizm, akne)<\/li>
        • Galaktore<\/li>
        • K\u0131sa boy<\/li>
        • Kalp \u00fcf\u00fcr\u00fcm\u00fc (Turner sendromu)<\/li><\/ul>

          de\u011ferlendirilmelidir.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

          \n\t\t\t\t\t
          \n\t\t\t\t
          \n\t\t\t\t\t\t\t\t\t

          Etiyolojik Ara\u015ft\u0131rma<\/h2>
          • Karyotip analizi<\/li>
          • Frajil X (FMR1 premutasyonu) testi<\/li>
          • 21-hidroksilaz antikorlar\u0131<\/li>
          • Anti-adrenal antikorlar<\/li>
          • Anti-tiroglobulin antikorlar\u0131<\/li>
          • Anti-TPO antikorlar\u0131<\/li>
          • \u00c7\u00f6lyak taramas\u0131<\/li>
          • HbA1c<\/li>
          • Uterus ve over ultrasonografisi<\/li>
          • Kemik mineral yo\u011funlu\u011fu \u00f6l\u00e7\u00fcm\u00fc
            • Patolojik sonu\u00e7 varsa her 2 y\u0131lda bir<\/li>
            • Normal sonu\u00e7 varsa her 5 y\u0131lda bir<\/li><\/ul><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
              \n\t\t\t\t\t
              \n\t\t\t\t
              \n\t\t\t\t\t\t\t\t\t

              Tedavi<\/h2>

              Tedavi, yumurtal\u0131klar\u0131n iki temel fonksiyonunu hedefler:<\/p>

              1. Hormon \u00fcretimi<\/li>
              2. Ovulasyon<\/li><\/ol>

                Hormon eksikli\u011fi, eksik olan hormonlar\u0131n (estradiol ve progesteron) d\u0131\u015far\u0131dan verilmesiyle yani hormon replasman tedavisi (HRT) ile giderilir. Bu tedavi, vazomotor semptomlar\u0131 ve POY\u2019nin uzun d\u00f6nem sonu\u00e7lar\u0131n\u0131 azaltmay\u0131 ama\u00e7lar.<\/p>

                \u00dcreme fonksiyonu ise:<\/p>

                • Yumurta ba\u011f\u0131\u015f\u0131<\/li>
                • Embriyo ba\u011f\u0131\u015f\u0131<\/li>
                • Yumurta dondurma<\/li>
                • Over dokusu kriyoprezervasyonu<\/li><\/ul>

                  ile desteklenebilir.<\/p>

                  Hormon Replasman Tedavisi<\/h2>

                  POY 12 ya\u015f\u0131ndan \u00f6nce tan\u0131nm\u0131\u015fsa ve puberte ba\u015flamam\u0131\u015fsa, \u00f6strojen tedavisine 11 ya\u015f\u0131nda ba\u015flan\u0131r. Puberte ba\u015flam\u0131\u015fsa tedavi hemen ba\u015flanmal\u0131d\u0131r.<\/p>

                  Pubertenin ba\u015flat\u0131lmas\u0131n\u0131n ama\u00e7lar\u0131:<\/p>

                  • Meme geli\u015fimi<\/li>
                  • Kemik mineralizasyonu (kalsiyum ve fosfor birikimi)<\/li>
                  • Adet d\u00f6ng\u00fclerinin sa\u011flanmas\u0131<\/li>
                  • \u00d6strojen varl\u0131\u011f\u0131n\u0131n s\u00fcrd\u00fcr\u00fclmesidir.<\/li><\/ul>

                    Ergenlikte \u00f6strojen tedavisi her 6 ayda bir kademeli olarak art\u0131r\u0131l\u0131r. B\u00f6ylece boy uzamas\u0131 kontroll\u00fc olur ve epifizlerin erken kapanmas\u0131 \u00f6nlenir.<\/p>

                    \u00d6strojen uygulama yollar\u0131:<\/p>

                    • Transdermal (17\u03b2-estradiol)<\/li>
                    • Oral (17\u03b2-estradiol, konjuge \u00f6strojenler, oral kontraseptifler)<\/li><\/ul>

                      Karaci\u011fer \u00fczerindeki etkiler ve tromboemboli riskinin daha d\u00fc\u015f\u00fck olmas\u0131 nedeniyle transdermal yol tercih edilir.<\/p>

                      Progesteron verilmesi:<\/p>

                      • Adet ba\u015flam\u0131\u015f kad\u0131nlarda zorunludur.<\/li>
                      • Ergenlikte, ilk adet ba\u015flamadan \u00f6nce yakla\u015f\u0131k iki y\u0131ll\u0131k \u00f6strojen tedavisinden sonra ba\u015flan\u0131r.<\/li><\/ul>

                        Kullan\u0131lan preparatlar:<\/p>

                        • Medroksiprogesteron asetat (MPA)<\/li>
                        • Do\u011fal progesteron<\/li><\/ul>

                          Her ikisi de benzer etkilidir; ancak do\u011fal progesteron daha az yan etkiye sahiptir. Alternatif olarak progesteronlu rahim i\u00e7i ara\u00e7 kullan\u0131labilir.<\/p>

                          E\u011fer hasta ayl\u0131k adet g\u00f6rmek istiyorsa:<\/p>

                          • Progesteron her ay 10\u201312 g\u00fcn verilir
                            (MPA 10 mg veya do\u011fal progesteron 200 mg)<\/li><\/ul>

                            Adet g\u00f6rmek istemiyorsa:<\/p>

                            • S\u00fcrekli tedavi uygulan\u0131r
                              (2,5\u20135 mg MPA veya 100 mg do\u011fal progesteron g\u00fcnl\u00fck)
                              ya da progesteronlu R\u0130A kullan\u0131labilir.<\/li><\/ul>

                              Tedavi do\u011fal menopoz ya\u015f\u0131 olan yakla\u015f\u0131k 51 ya\u015f\u0131na kadar s\u00fcrd\u00fcr\u00fcl\u00fcr.<\/p>

                              Bu tedavi gebelikten koruma sa\u011flamaz; \u00e7\u00fcnk\u00fc %5\u201310 oran\u0131nda spontan gebelik bildirilmi\u015ftir. Bu nedenle progesteronlu veya bak\u0131rl\u0131 R\u0130A g\u00fcvenle kullan\u0131labilir.<\/p>

                              Gebelik \u0130ste\u011fi<\/h2>

                              Ergenlerde %20\u201325 oran\u0131nda spontan ovulasyon g\u00f6r\u00fclebilir. Bu nedenle POY\u2019nin erken evrelerinde:<\/p>

                              • Yumurta dondurma<\/li>
                              • Over dokusu kriyoprezervasyonu<\/li><\/ul>

                                \u00f6nerilir.<\/p>

                                Over dokusu kriyoprezervasyonunda, gebelik istenildi\u011finde laboratuvarda folik\u00fcl stim\u00fclasyonu yap\u0131ld\u0131ktan sonra doku yeniden nakledilir.<\/p>

                                Yumurta ba\u011f\u0131\u015f\u0131 ile:<\/p>

                                • Tek siklusta yakla\u015f\u0131k %40<\/li>
                                • D\u00f6rt siklus sonunda %70\u201380<\/li><\/ul>

                                  gebelik oran\u0131 elde edilmektedir.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

                                  Premat\u00fcre over yetmezli\u011fi (POY), 40 ya\u015f alt\u0131ndaki kad\u0131nlar\u0131n %1\u2019inde g\u00f6r\u00fcl\u00fcr. Bu ya\u015f\u0131n alt\u0131nda adet g\u00f6rmeyen bir kad\u0131nda POY bulunma olas\u0131l\u0131\u011f\u0131 ise %5\u201310\u2019dur. Yumurtal\u0131klar normalde bir yandan [\u2026]<\/span><\/p>\n","protected":false},"author":3,"featured_media":-1,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[78,80],"tags":[84],"class_list":["post-1458","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jinekoloji","category-subfertilite","tag-premature-over-yetmezligi"],"yoast_head":"\nPremat\u00fcre Over Yetmezli\u011fi (POY) - \u0391\u03bb\u03ad\u03be\u03b1\u03bd\u03b4\u03c1\u03bf\u03c2 \u039c\u03ac\u03b9\u03bd\u03b1\u03c2 MD, PhD<\/title>\n<meta name=\"description\" content=\"Premat\u00fcre over yetmezli\u011fi (POY), 40 ya\u015f alt\u0131ndaki kad\u0131nlar\u0131n %1\u2019inde g\u00f6r\u00fcl\u00fcr. Bu ya\u015f\u0131n alt\u0131nda adet g\u00f6rmeyen bir kad\u0131nda POY bulunma olas\u0131l\u0131\u011f\u0131 ise %5\u201310\u2019dur.\" \/>\n<meta name=\"robots\" content=\"noindex, follow\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Premat\u00fcre Over Yetmezli\u011fi (POY) - \u0391\u03bb\u03ad\u03be\u03b1\u03bd\u03b4\u03c1\u03bf\u03c2 \u039c\u03ac\u03b9\u03bd\u03b1\u03c2 MD, PhD\" \/>\n<meta property=\"og:description\" content=\"Premat\u00fcre over yetmezli\u011fi (POY), 40 ya\u015f alt\u0131ndaki kad\u0131nlar\u0131n %1\u2019inde g\u00f6r\u00fcl\u00fcr. Bu ya\u015f\u0131n alt\u0131nda adet g\u00f6rmeyen bir kad\u0131nda POY bulunma olas\u0131l\u0131\u011f\u0131 ise %5\u201310\u2019dur.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/gynaikologos-komotini.gr\/tr\/premature-over-yetmezligi-poy\/\" \/>\n<meta property=\"og:site_name\" content=\"\u0391\u03bb\u03ad\u03be\u03b1\u03bd\u03b4\u03c1\u03bf\u03c2 \u039c\u03ac\u03b9\u03bd\u03b1\u03c2 MD, PhD\" \/>\n<meta property=\"article:published_time\" content=\"2026-05-07T09:48:10+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-07T09:55:47+00:00\" \/>\n<meta name=\"author\" content=\"gynaikologos-komotini.gr\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"gynaikologos-komotini.gr\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/gynaikologos-komotini.gr\\\/tr\\\/premature-over-yetmezligi-poy\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/gynaikologos-komotini.gr\\\/tr\\\/premature-over-yetmezligi-poy\\\/\"},\"author\":{\"name\":\"gynaikologos-komotini.gr\",\"@id\":\"https:\\\/\\\/gynaikologos-komotini.gr\\\/tr\\\/#\\\/schema\\\/person\\\/b9885b126f4a66f54449cbe60345b30f\"},\"headline\":\"Premat\u00fcre Over Yetmezli\u011fi (POY)\",\"datePublished\":\"2026-05-07T09:48:10+00:00\",\"dateModified\":\"2026-05-07T09:55:47+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/gynaikologos-komotini.gr\\\/tr\\\/premature-over-yetmezligi-poy\\\/\"},\"wordCount\":1111,\"keywords\":[\"Premat\u00fcre over yetmezli\u011fi\"],\"articleSection\":[\"Jinekoloji\",\"Subfertilite\"],\"inLanguage\":\"tr\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/gynaikologos-komotini.gr\\\/tr\\\/premature-over-yetmezligi-poy\\\/\",\"url\":\"https:\\\/\\\/gynaikologos-komotini.gr\\\/tr\\\/premature-over-yetmezligi-poy\\\/\",\"name\":\"Premat\u00fcre Over Yetmezli\u011fi (POY) - \u0391\u03bb\u03ad\u03be\u03b1\u03bd\u03b4\u03c1\u03bf\u03c2 \u039c\u03ac\u03b9\u03bd\u03b1\u03c2 MD, PhD\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/gynaikologos-komotini.gr\\\/tr\\\/#website\"},\"datePublished\":\"2026-05-07T09:48:10+00:00\",\"dateModified\":\"2026-05-07T09:55:47+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/gynaikologos-komotini.gr\\\/tr\\\/#\\\/schema\\\/person\\\/b9885b126f4a66f54449cbe60345b30f\"},\"description\":\"Premat\u00fcre over yetmezli\u011fi (POY), 40 ya\u015f alt\u0131ndaki kad\u0131nlar\u0131n %1\u2019inde g\u00f6r\u00fcl\u00fcr. Bu ya\u015f\u0131n alt\u0131nda adet g\u00f6rmeyen bir kad\u0131nda POY bulunma olas\u0131l\u0131\u011f\u0131 ise %5\u201310\u2019dur.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/gynaikologos-komotini.gr\\\/tr\\\/premature-over-yetmezligi-poy\\\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/gynaikologos-komotini.gr\\\/tr\\\/premature-over-yetmezligi-poy\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/gynaikologos-komotini.gr\\\/tr\\\/premature-over-yetmezligi-poy\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"\u0391\u03c1\u03c7\u03b9\u03ba\u03ae\",\"item\":\"https:\\\/\\\/gynaikologos-komotini.gr\\\/tr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Premat\u00fcre Over Yetmezli\u011fi (POY)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/gynaikologos-komotini.gr\\\/tr\\\/#website\",\"url\":\"https:\\\/\\\/gynaikologos-komotini.gr\\\/tr\\\/\",\"name\":\"\u0391\u03bb\u03ad\u03be\u03b1\u03bd\u03b4\u03c1\u03bf\u03c2 \u039c\u03ac\u03b9\u03bd\u03b1\u03c2 MD, PhD\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/gynaikologos-komotini.gr\\\/tr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"tr\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/gynaikologos-komotini.gr\\\/tr\\\/#\\\/schema\\\/person\\\/b9885b126f4a66f54449cbe60345b30f\",\"name\":\"gynaikologos-komotini.gr\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Premat\u00fcre Over Yetmezli\u011fi (POY) - \u0391\u03bb\u03ad\u03be\u03b1\u03bd\u03b4\u03c1\u03bf\u03c2 \u039c\u03ac\u03b9\u03bd\u03b1\u03c2 MD, PhD","description":"Premat\u00fcre over yetmezli\u011fi (POY), 40 ya\u015f alt\u0131ndaki kad\u0131nlar\u0131n %1\u2019inde g\u00f6r\u00fcl\u00fcr. Bu ya\u015f\u0131n alt\u0131nda adet g\u00f6rmeyen bir kad\u0131nda POY bulunma olas\u0131l\u0131\u011f\u0131 ise %5\u201310\u2019dur.","robots":{"index":"noindex","follow":"follow"},"og_locale":"tr_TR","og_type":"article","og_title":"Premat\u00fcre Over Yetmezli\u011fi (POY) - \u0391\u03bb\u03ad\u03be\u03b1\u03bd\u03b4\u03c1\u03bf\u03c2 \u039c\u03ac\u03b9\u03bd\u03b1\u03c2 MD, PhD","og_description":"Premat\u00fcre over yetmezli\u011fi (POY), 40 ya\u015f alt\u0131ndaki kad\u0131nlar\u0131n %1\u2019inde g\u00f6r\u00fcl\u00fcr. Bu ya\u015f\u0131n alt\u0131nda adet g\u00f6rmeyen bir kad\u0131nda POY bulunma olas\u0131l\u0131\u011f\u0131 ise %5\u201310\u2019dur.","og_url":"https:\/\/gynaikologos-komotini.gr\/tr\/premature-over-yetmezligi-poy\/","og_site_name":"\u0391\u03bb\u03ad\u03be\u03b1\u03bd\u03b4\u03c1\u03bf\u03c2 \u039c\u03ac\u03b9\u03bd\u03b1\u03c2 MD, PhD","article_published_time":"2026-05-07T09:48:10+00:00","article_modified_time":"2026-05-07T09:55:47+00:00","author":"gynaikologos-komotini.gr","twitter_card":"summary_large_image","twitter_misc":{"Yazan:":"gynaikologos-komotini.gr","Tahmini okuma s\u00fcresi":"5 dakika"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/gynaikologos-komotini.gr\/tr\/premature-over-yetmezligi-poy\/#article","isPartOf":{"@id":"https:\/\/gynaikologos-komotini.gr\/tr\/premature-over-yetmezligi-poy\/"},"author":{"name":"gynaikologos-komotini.gr","@id":"https:\/\/gynaikologos-komotini.gr\/tr\/#\/schema\/person\/b9885b126f4a66f54449cbe60345b30f"},"headline":"Premat\u00fcre Over Yetmezli\u011fi (POY)","datePublished":"2026-05-07T09:48:10+00:00","dateModified":"2026-05-07T09:55:47+00:00","mainEntityOfPage":{"@id":"https:\/\/gynaikologos-komotini.gr\/tr\/premature-over-yetmezligi-poy\/"},"wordCount":1111,"keywords":["Premat\u00fcre over yetmezli\u011fi"],"articleSection":["Jinekoloji","Subfertilite"],"inLanguage":"tr"},{"@type":"WebPage","@id":"https:\/\/gynaikologos-komotini.gr\/tr\/premature-over-yetmezligi-poy\/","url":"https:\/\/gynaikologos-komotini.gr\/tr\/premature-over-yetmezligi-poy\/","name":"Premat\u00fcre Over Yetmezli\u011fi (POY) - \u0391\u03bb\u03ad\u03be\u03b1\u03bd\u03b4\u03c1\u03bf\u03c2 \u039c\u03ac\u03b9\u03bd\u03b1\u03c2 MD, PhD","isPartOf":{"@id":"https:\/\/gynaikologos-komotini.gr\/tr\/#website"},"datePublished":"2026-05-07T09:48:10+00:00","dateModified":"2026-05-07T09:55:47+00:00","author":{"@id":"https:\/\/gynaikologos-komotini.gr\/tr\/#\/schema\/person\/b9885b126f4a66f54449cbe60345b30f"},"description":"Premat\u00fcre over yetmezli\u011fi (POY), 40 ya\u015f alt\u0131ndaki kad\u0131nlar\u0131n %1\u2019inde g\u00f6r\u00fcl\u00fcr. Bu ya\u015f\u0131n alt\u0131nda adet g\u00f6rmeyen bir kad\u0131nda POY bulunma olas\u0131l\u0131\u011f\u0131 ise %5\u201310\u2019dur.","breadcrumb":{"@id":"https:\/\/gynaikologos-komotini.gr\/tr\/premature-over-yetmezligi-poy\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/gynaikologos-komotini.gr\/tr\/premature-over-yetmezligi-poy\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/gynaikologos-komotini.gr\/tr\/premature-over-yetmezligi-poy\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"\u0391\u03c1\u03c7\u03b9\u03ba\u03ae","item":"https:\/\/gynaikologos-komotini.gr\/tr\/"},{"@type":"ListItem","position":2,"name":"Premat\u00fcre Over Yetmezli\u011fi (POY)"}]},{"@type":"WebSite","@id":"https:\/\/gynaikologos-komotini.gr\/tr\/#website","url":"https:\/\/gynaikologos-komotini.gr\/tr\/","name":"\u0391\u03bb\u03ad\u03be\u03b1\u03bd\u03b4\u03c1\u03bf\u03c2 \u039c\u03ac\u03b9\u03bd\u03b1\u03c2 MD, PhD","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/gynaikologos-komotini.gr\/tr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"tr"},{"@type":"Person","@id":"https:\/\/gynaikologos-komotini.gr\/tr\/#\/schema\/person\/b9885b126f4a66f54449cbe60345b30f","name":"gynaikologos-komotini.gr"}]}},"_links":{"self":[{"href":"https:\/\/gynaikologos-komotini.gr\/tr\/wp-json\/wp\/v2\/posts\/1458","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gynaikologos-komotini.gr\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gynaikologos-komotini.gr\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gynaikologos-komotini.gr\/tr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/gynaikologos-komotini.gr\/tr\/wp-json\/wp\/v2\/comments?post=1458"}],"version-history":[{"count":3,"href":"https:\/\/gynaikologos-komotini.gr\/tr\/wp-json\/wp\/v2\/posts\/1458\/revisions"}],"predecessor-version":[{"id":1463,"href":"https:\/\/gynaikologos-komotini.gr\/tr\/wp-json\/wp\/v2\/posts\/1458\/revisions\/1463"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gynaikologos-komotini.gr\/tr\/wp-json\/"}],"wp:attachment":[{"href":"https:\/\/gynaikologos-komotini.gr\/tr\/wp-json\/wp\/v2\/media?parent=1458"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gynaikologos-komotini.gr\/tr\/wp-json\/wp\/v2\/categories?post=1458"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gynaikologos-komotini.gr\/tr\/wp-json\/wp\/v2\/tags?post=1458"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}